The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.Research Article Published on 2022-01-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used [DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article
Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant대식세포에서 칸디다 알비칸스의 소진화는 필라멘트가 아닌 돌연변이에서 필라멘트를 복원합니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Antifungal treatment approach avirulent C. albican C. albicans Candida Candida albican Candida albicans Cdk8 Cell cell wall clinical setting complex component Compound connection drug resistance ENCODE environmental cue environmental cues Evolution example exhibited fungi gene encoding growth hosts hyphae hyphal identify in vivo Incubation induce Infection leads Macrophage macrophages maintain mechanism mediator Mediator complex microbe microevolution microevolutionary microorganism microorganisms Missense mutation murine mutant Mutation nucleotide pathogenic pathogenicity phagocytosis regulatory network responsible selection pressure Signaling signaling pathway single nucleotide strain subject the macrophage phagosome These data took place Transcription transcription factor transcription factors transcription regulation transcriptional transcriptional regulation undergo virulence whole genome yeast [DOI] 10.1371/journal.pgen.1004824 PMC 바로가기 [Article Type] Research Article